The heat-shock proteins.

PERSPECTIVES ANDUMMARY .............................................................. 632 HSP110 .................................................................................................. 634 THE HSP 90 FAMILY .............................................................................. 634 Biochemical Analysis ............................................................................. 636 Genetic Analysis .................................................................................. 639 THE HSP70 FAMILY ............................................................................... 641 Drosophila melanogaster ........................................................................ 641 Saccharomyces revisiae ....................................................................... 642 E. coli ............................................................................................... 645 Mammalian Cells ................................................................................. 648 Discussion of hsp70 Function .................................................................. 652 THE SMALL HSPS .................................................................................. 652 GROE HSP58 .......................................................................................... 653 UBIQUITIN ............................................................................................ 658 OTHER P OTEINS .................................................................................. 659 Eukarvotes .......................................................................................... 659 Proka’ryotes ........................................................................................ 661 Thermotolerance .................................................................................. 661 The Correlation Between Hsp Synthesis and Thermotolerance .......................... 662 Mutations That Alter ttsp Synthesis ........................................................... 663 REGULATION OF THE RESPONSE ............................................................ 665 CONCLUDING REMARKS ........................................................................ 666